Objective. Oral mucosa could host many lesions originated by chronic mechanical irritation (CMI) from teeth or dentures, and it\nhas been proposed as risk factor for oral cancer. Nevertheless, the features of CMI factors in oral cancer and other lesions are not\nassessed. The aim of this study is to describe CMI features regarding type (dental, prosthetic, and/or functional), localization,\nand time span. Materials and Methods. Three groups were studied in this cross-sectional study: Oral Cancer (OC); Chronic\nTraumatic Ulcer (CTU); and Benign Irritative Mechanical Lesions (BIML). All sources of mechanical irritation were included:\ndental, prosthetic, and functional. Results. 285 patients (176 females, 109males) were studied: OC = 38, CTU = 44, and BIML = 203.\nThemost frequent CMI factor was dental, followed by functional and prosthetic in all groups; 76.5% (
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